|
KMID : 0369819820120010001
|
|
Jorunal of Korean Pharmaceutical Sciences
1982 Volume.12 No. 1 p.1 ~ p.11
|
|
|
Pharmaceutical Study on Zinc Sulfadiazine Ointments
|
|
이명연/Lee MY
지웅길/김양서/Jee UK/Kim YS
|
|
|
Abstract
|
|
|
|
Silver sulfadiazine has been introduced to replace silver nitrate in the topical treatment of extensive burns and this drug exerts a prominent antibacterial action against Pseudomonas aeruginosa. The compound is painless upon application and insufficient sulfadiazine is absorbed to cause crystalluria. The primary purpose of the study was to clarify the antimicrobial action of zinc sulfadiazine ointment in comparison with silver sulfadiazine ointment as well as the pharmaceutical properties of the zinc sulfadiazine preparations. The results are summerized as followings: 1) The optimum ratio of two substrate compounds for the synthesis of zinc sulfadiazine are 2 moles of sulfadiazine and 1 mole of zinc sulfate at pH 6.0. 2) The stability of zinc sulfadiazine ointment preparation by using polyethylene glycol base, Beeler's base or polyoxyl 40 stearate base was more stable than that of silver sulfadiazine preparations. 3) The antimicrobial action of zinc sulfadiazine exhibits a stronger antimicrobial activity than that of sulfadiazine against Staphylococcus aureus but the opposite is true against Pseudomonas aeruginosa.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|